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Holger Wille

Ph.D. Associate Professor

wille@ualberta.ca

(780) 248-1712

I joined the University of Alberta in February, 2012, as Associate Professor in the Department of Biochemistry and The Centre for Prions and Protein Folding Diseases.  The general focus of my work is the structure of amyloids and other disease-related, misfolded proteins. In particular, I am interested in the infectious prion protein (PrPSc) and the structure-function relationship underlying its infectious nature. In recent years, mounting evidence has implicated prion-like mechanisms in other neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Lou Gehrig’s disease. The mechanistic similarities and their molecular underpinnings represent interesting research avenues beyond the classical prion diseases.