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Satyabrata Kar

Ph.D. Professor

(780) 492-9357

Research in my lab focuses on two complementary themes relating to the pathogenesis of Alzheimer’s disease (AD). The first program: Aβ-related peptides and central cholinergic neurons in AD pathology is designed to address the role of β-amyloid (Aβ) peptides in the regulation of function/survival of cholinergic/glutamatergic neurons and their relevance to AD pathology. The second project: IGFs in normal brain and their possible implication in AD pathology is aimed to study the role of insulin-like growth factor-II (IGF-II) receptor, which regulates trafficking of certain lysosomal enzymes involved in the production of Aβ peptides and/or survival of neurons, in normal brain function and their implications in AD pathology.

The overall objective of these two projects is to establish the cause of preferential vulnerability of the cholinergic/glutamatergic neurons in AD and to determine how these neurons can be protected against Ab-mediated toxicity.

Also please check out these links in more deteail: lab, Psychiatry.