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Recent Alzheimer Disease Publications

Leighton PL, Allison WT. "Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function." J Alzheimers Dis. 2016 Jul 6;54(1):3-29. doi: 10.3233/JAD-160361. PMID: 27392869

Wang Y, MacDonald RG, Thinakaran G, Kar S. "Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases." Mol Neurobiol. 2016 Mar 19. [Epub ahead of print] Review. PMID: 26993302

Ourdev D, Foroutanpay BV, Wang Y, Kar S. "The Effect of Aβ₁₋₄₂ Oligomers on APP Processing and Aβ₁₋₄₀ Generation in Cultured U-373 Astrocytes." Neurodegener Dis. 2015;15(6):361-8. doi: 10.1159/000438923. Epub 2015 Oct 20. PMID: 26606591

Maulik M, Peake K, Chung J, Wang Y, Vance JE, Kar S. "APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease." Hum Mol Genet. 2015 Dec 15;24(24):7132-50. doi: 10.1093/hmg/ddv413. Epub 2015 Oct 3. PMID: 26433932

DeCarlo CA, MacDonald SW, Vergote D, Jhamandas J, Westaway D, Dixon RA. "Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study." J Gerontol B Psychol Sci Soc Sci. 2015 Sep 11. pii: gbv043. PMID: 26362601

Kumar J, Namsechi R, Sim VL. "Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity." PLoS One. 2015 Jun 12;10(6):e0129087. doi: 10.1371/journal.pone.0129087. eCollection 2015. PMID: 26070139

Wang Y, Buggia-Prévot V, Zavorka ME, Bleackley RC, MacDonald RG, Thinakaran G, Kar S. "Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability." Mol Cell Biol. 2015 Jul;35(14):2368-84. doi: 10.1128/MCB.01338-14. Epub 2015 May 4. PMID: 25939386

Fu W, Shi D, Westaway D, Jhamandas JH. "Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity." J Biol Chem. 2015 Mar 26. pii: jbc.M114.618157. [Epub ahead of print] PMID: 25814669

McFall GP, Wiebe SA, Vergote D, Westaway D, Jhamandas J, Bäckman L, Dixon RA. "ApoE and Pulse Pressure Interactively Influence Level and Change in the Aging of Episodic Memory: Protective Effects Among ε2 Carriers." Neuropsychology. 2014 Dec 1. [Epub ahead of print] PMID: 25436424

Dixon RA, DeCarlo CA, MacDonald SW, Vergote D, Jhamandas J, Westaway D. "APOE and COMT polymorphisms are complementary biomarkers of status, stability, and transitions in normal aging and early mild cognitive impairment." Front Aging Neurosci. 2014 Sep 5;6:236. doi: 10.3389/fnagi.2014.00236. eCollection 2014. PMID: 25249975

Peng J, Guo K, Xia J, Zhou J, Yang J, Westaway D, Wishart DS, Li L. "Development of isotope labeling liquid chromatography mass spectrometry for mouse urine metabolomics: quantitative metabolomic study of transgenic mice related to Alzheimer's disease." J Proteome Res. 2014 Oct 3;13(10):4457-69. doi: 10.1021/pr500828v. Epub 2014 Sep 15. PMID: 25164377

Sapkota S, Vergote D, Westaway D, Jhamandas J, Dixon RA. "Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E." Neurobiol Aging. 2015 Jan;36(1):249-56. doi: 10.1016/j.neurobiolaging.2014.06.020. Epub 2014 Jun 20. PMID: 25107496

Haile Y, Fu W, Shi B, Westaway D, Baker G, Jhamandas J, Giuliani F. "Characterization of the NT2-derived neuronal and astrocytic cell lines as alternative in vitro models for primary human neurons and astrocytes." J Neurosci Res. 2014 May 7. doi: 10.1002/jnr.23399. PMID: 24801011

McFall, G.P., Wiebe, S.A., Vergote, D.; Jhamandas, J., Westaway, D., Dixon, R.; (2013) “IDE (rs6583817) and pulse pressure are independently associated with level and change in executive function in older adults." Psychology and Aging, in press.

Religa P, Cao R, Religa D, Xue Y, Bogdanovic N, Westaway D, Marti HH, Winblad B, Cao Y. RA"VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival." Sci Rep. 2013;3:2053. doi: 10.1038/srep02053. PMID: 23792494

McFall GP, Wiebe SA, Vergote D, Westaway D, Jhamandas J, Dixon RA"IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults." Neurobiol Aging. 2013 Sep;34(9):2208-16. doi: 10.1016/j.neurobiolaging.2013.03.010. Epub 2013 Apr 16. PMID: 23597493

Vardarajan B, Vergote D, Tissir F, Logue M, Yang J, Daude N, Ando K, Rogaeva E, Lee J, Cheng R, Brion JP, Ghani M, Shi B, Baldwin CT, Kar S, Mayeux R, Fraser P, Goffinet AM, George-Hyslop PS, Farrer LA, Westaway D."Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts." Mol Neurodegener. 2013 Feb 15;8:10. doi: 10.1186/1750-1326-8-10. PMID: 23414597

Maulik M, Thinakaran G, Kar S."Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 protein." PLoS One. 2013;8(1):e54605. doi: 10.1371/journal.pone.0054605. Epub 2013 Jan 29. PMID: 23382922

Amritraj A, Wang Y, Revett TJ, Vergote D, Westaway D, Kar S."Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis." J Biol Chem. 2013 Feb 1;288(5):3136-52. doi: 10.1074/jbc.M112.412460. Epub 2012 Dec 17. PMID: 23250759

Darcy M. Kaiser1, Moulinath Acharya1, Patricia L. A. Leighton, Hao Wang, Nathalie Daude, Serene Wohlgemuth, Beipei Shi, W. Ted Allison"Amyloid Beta Precursor Protein and Prion Protein Have a Conserved Interaction Affecting Cell Adhesion and CNS Development." PLoS ONE 7(12): e51305. doi:10.1371/journal.pone.0051305 PMID: 23236467

Kimura R, MacTavish D, Yang J, Westaway D, and Jhamandas JH. "Beta amyloid (Aβ)-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor." J Neurosci. 2012 Nov 28;32(48):17401-6. doi: 10.1523/JNEUROSCI.3028-12.2012. PMID: 23197731

Brautigam H, Steele JW, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. "The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease." Mol Neurodegener. 2012 Nov 22;7:58. doi: 10.1186/1750-1326-7-58. PMID: 23173713

Maulik M, Westaway D, Jhamandas JH, Kar S. "Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer's Disease Pathogenesis." Mol Neurobiol. 2013 Feb;47(1):37-63. doi: 10.1007/s12035-012-8337-y. Epub 2012 Sep 16. PMID: 22983915

Amritraj A, Posse de Chaves EI, Hawkes C, Macdonald RG, Kar S. "Single-transmembrane domain IGF-II/M6P receptor: potential interaction with G protein and its association with cholesterol-rich membrane domains." Endocrinology. 2012 Oct;153(10):4784-98. Epub 2012 Aug 17. PMID: 22903618

Revett TJ, Baker GB, Jhamandas J, Kar S. "Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology." J Psychiatry Neurosci. 2012 Aug 14;37(5):110190. doi: 10.1503/jpn.110190. [Epub ahead of print] In PressPMID: 22894822

Westaway D, Jhamandas JH. "The P's and Q's of cellular PrP-Aβ interactions." Prion. 2012 Sep 1;6(4):359-63. Epub 2012 Aug 9. PMID: 22874673

Maulik M, Ghoshal B, Kim J, Wang Y, Yang J, Westaway D, Kar S. "Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin." Hum Mol Genet. 2012 Aug 29. [Epub ahead of print] PMID: 22869680

Alier K, Ma L, Yang J, Westaway D, Jhamandas JH. "Aβ Inhibition of Ionic Conductance in Mouse Basal Forebrain Neurons Is Dependent upon the Cellular Prion Protein PrPC." J Neurosci. 2011 Nov 9;31(45):16292-7. PMID: 22072680

Amtul Z, Keet M, Wang L, Merrifield P, Westaway D, Rozmahel RF. "DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet?" PLoS One. 2011;6(9):e24094. Epub 2011 Sep 8. PMID: 21931647

Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA. "Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis." Autophagy. 2011 Jul;7(7):788-9. Epub 2011 Jul 1. PMID: 21464620

Song MS, Baker GB, Todd KG, Kar S. "Inhibition of β-amyloid1-42 internalization attenuates neuronal death by stabilizing the endosomal-lysosomal system in rat cortical cultured neurons." Neuroscience. 2011 Mar 31;178:181-8. doi: 10.1016/j.neuroscience.2010.12.055. Epub 2011 Jan 21. PMID: 21262324

Jhamandas JH, Li Z, Westaway D, Yang J, Jassar S, MacTavish D. "Actions of β-amyloid protein on human neurons are expressed through the amylin receptor." Am J Pathol. 2011 Jan;178(1):140-9. Epub 2010 Dec 23. PMID: 21224052

Amtul Z, Wang L, Westaway D, Rozmahel RF. "Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease" Neuroscience. 2010 Aug 25;169(2):781-6. Epub 2010 May 21. PMID: 20493928

Kuzyk A, Kastyak M, Agrawal V, Gallant M, Sivakumar G, Rak M, Del Bigio MR, Westaway D, Julian R, Gough KM. "Association between amyloid plaque, lipid, and creatine in hippocampus of TgCRND8 mouse model for Alzheimer disease " J Biol Chem. 2010 Aug 3. PMID: 20682779

Kodam A, Maulik M, Peake K, Amritraj A, Vetrivel KS, Thinakaran G, Vance JE, Kar S. "Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains" Glia 2010 Aug 15;58(11):1267-81. PMID: 20607864

Amritraj A, Rauw G, Baker GB, Kar S. "Leu(27) insulin-like growth factor-II, an insulin-like growth factor-II analog, attenuates depolarization-evoked GABA release from adult rat hippocampal and cortical slices" Neuroscience. 2010 Jul 24. [Epub ahead of print] PMID: 20659530

Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA. "Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations" Cell 2010 Jun 25;141(7):1146-58. Epub 2010 Jun 10. PMID: 20541250

Soong Ho Kim, Paul Fraser, David Westaway, Peter St George-Hyslop, Michelle Ehrlich, and Samuel Gandy " Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid Aβ42 from isolated intact nerve terminals" J. Neuroscience 2010, Mar 17;30(11):3870-5. PMID: 20237257

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